PittsburghV1, Main, Exploration, bibRecord, 005079

Preoperative GNAS and KRAS Testing in the Diagnosis of Pancreatic Mucinous Cysts

Identifieur interne : 005079 ( Main/Exploration ); précédent : 005078; suivant : 005080

Preoperative GNAS and KRAS Testing in the Diagnosis of Pancreatic Mucinous Cysts

Auteurs : Aatur D. Singhi [États-Unis] ; Marina N. Nikiforova [États-Unis] ; Kenneth E. Fasanella [États-Unis] ; Kevin M. Mcgrath [États-Unis] ; Reetesh K. Pai [États-Unis] ; N. Paul Ohori [États-Unis] ; Tanner L. Bartholow [États-Unis] ; Randall E. Brand [États-Unis] ; Jennifer S. Chennat [États-Unis] ; XUONG LU [États-Unis] ; Georgios I. Papachristou [États-Unis] ; Adam Slivka [États-Unis] ; Herbert J. Zeh [États-Unis] ; Amer H. Zureikat [États-Unis] ; Kenneth K. Lee [États-Unis] ; ALLAN TSUNG [États-Unis] ; Geeta S. Mantha [États-Unis] ; Asif Khalid [États-Unis]

Source :

Clinical cancer research : (Print) [ 1078-0432 ] ; 2014.

RBID : Pascal:14-0227741

Descripteurs français

English descriptors

KwdEn :
- Adenocarcinoma (diagnosis), Adenocarcinoma (genetics), Adenocarcinoma, Mucinous (diagnosis), Adenocarcinoma, Mucinous (genetics), Adult, Aged, Aged, 80 and over, Biomarkers, Tumor (genetics), Biopsy, Fine-Needle, C-Onc gene, Carcinoma, Pancreatic Ductal (diagnosis), Carcinoma, Pancreatic Ductal (genetics), Carcinoma, Papillary (diagnosis), Carcinoma, Papillary (genetics), Chromogranins, Cyst Fluid (chemistry), Cyst Fluid (metabolism), Cystadenoma, Serous (diagnosis), Cystadenoma, Serous (genetics), Diagnosis, Female, Follow-Up Studies, GTP-Binding Protein alpha Subunits, Gs (genetics), Humans, K ras Gene, Male, Medical screening, Middle Aged, Mutation (genetics), Neoplasm Staging, Pancreatic Cyst (metabolism), Pancreatic Cyst (pathology), Pancreatic Neoplasms (diagnosis), Pancreatic Neoplasms (genetics), Pancreatic cyst, Preoperative, Preoperative Care, Prognosis, Proto-Oncogene Proteins (genetics), Proto-Oncogene Proteins p21(ras), Protooncogene, Young Adult, ras Proteins (genetics).
MESH :
- chemical , genetics : Biomarkers, Tumor, GTP-Binding Protein alpha Subunits, Gs, Proto-Oncogene Proteins, ras Proteins.
- chemistry : Cyst Fluid.
- diagnosis : Adenocarcinoma, Adenocarcinoma, Mucinous, Carcinoma, Pancreatic Ductal, Carcinoma, Papillary, Cystadenoma, Serous, Pancreatic Neoplasms.
- genetics : Adenocarcinoma, Adenocarcinoma, Mucinous, Carcinoma, Pancreatic Ductal, Carcinoma, Papillary, Cystadenoma, Serous, Mutation, Pancreatic Neoplasms.
- metabolism : Cyst Fluid, Pancreatic Cyst.
- pathology : Pancreatic Cyst.
- Adult, Aged, Aged, 80 and over, Biopsy, Fine-Needle, Chromogranins, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Preoperative Care, Prognosis, Proto-Oncogene Proteins p21(ras), Young Adult.

Abstract

Purpose: Management guidelines for pancreatic intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN) are based on the assumption that mucinous cysts can be accurately distinguished from other pancreatic cystic lesions. Previous studies using surgical material have identified recurrent mutations in GNAS and KRAS in pancreatic mucinous neoplasms. Yet, the diagnostic utility of testing for both genes in pancreatic cyst fluid obtained by endoscopic ultrasound-fine-needle aspiration (EUS-FNA) remains unclear. Experimental Design: GNAS and KRAS testing was performed on EUS-FNA pancreatic cyst fluid from 91 pancreatic cysts: 41 IPMNs, 9 IPMNs with adenocarcinoma, 16 MCNs, 10 cystic pancreatic neuroendocrine tumors (PanNET), 9 serous cystadenomas (SCA), 3 retention cysts, 2 pseudocysts, and 1 lymphoepithelial cyst. Results: Mutations in GNAS were detected in 16 (39%) IPMNs and 2 (22%) IPMNs with adenocarcinoma. KRAS mutations were identified in 28 (68%) IPMNs, 7 (78%) IPMNs with adenocarcinoma, and 1 (6%) MCN. Mutations in either gene were present in 34 (83%) IPMNs, 8 (89%) IPMNs with adenocarcinoma, and 1 (6%) MCN. No mutations were found in cystic PanNETs, SCAs, retention cysts, pseudocysts, and a lymphoepithelial cyst. GNAS and KRAS mutations had 100% specificity [95% confidence interval (CI), 0.83-1.00] but 65% sensitivity (95% CI, 0.52-0.76) for mucinous differentiation. Among IPMNs, mutations in either gene had 98% specificity (95% CI, 0.86-1.00) and 84% sensitivity (95% CI, 0.70-0.92). Conclusions: The combination of GNAS and KRAS testing was highly specific and sensitive for IPMNs; however, the lack of sensitivity for MCNs highlights the need for additional markers to improve the detection of pancreatic mucinous neoplasms.

Affiliations:

Le document en format XML

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<author><name sortKey="Ohori, N Paul" sort="Ohori, N Paul" uniqKey="Ohori N" first="N. Paul" last="Ohori">N. Paul Ohori</name>
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<country>États-Unis</country>
<wicri:noRegion>Department of Pathology, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bartholow, Tanner L" sort="Bartholow, Tanner L" uniqKey="Bartholow T" first="Tanner L." last="Bartholow">Tanner L. Bartholow</name>
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<country>États-Unis</country>
<wicri:noRegion>Department of Pathology, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brand, Randall E" sort="Brand, Randall E" uniqKey="Brand R" first="Randall E." last="Brand">Randall E. Brand</name>
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<s3>USA</s3>
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<country>États-Unis</country>
<wicri:noRegion>Department of Medicine, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chennat, Jennifer S" sort="Chennat, Jennifer S" uniqKey="Chennat J" first="Jennifer S." last="Chennat">Jennifer S. Chennat</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, the University of Pittsburgh Medical Center</s1>
<s3>USA</s3>
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<country>États-Unis</country>
<wicri:noRegion>Department of Medicine, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xuong Lu" sort="Xuong Lu" uniqKey="Xuong Lu" last="Xuong Lu">XUONG LU</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, the University of Pittsburgh Medical Center</s1>
<s3>USA</s3>
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<country>États-Unis</country>
<wicri:noRegion>Department of Medicine, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Papachristou, Georgios I" sort="Papachristou, Georgios I" uniqKey="Papachristou G" first="Georgios I." last="Papachristou">Georgios I. Papachristou</name>
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<s3>USA</s3>
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<country>États-Unis</country>
<wicri:noRegion>Department of Medicine, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>VA Pittsburgh Healthcare System</s1>
<s2>Pittsburgh, Pennsylvania</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Slivka, Adam" sort="Slivka, Adam" uniqKey="Slivka A" first="Adam" last="Slivka">Adam Slivka</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, the University of Pittsburgh Medical Center</s1>
<s3>USA</s3>
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<country>États-Unis</country>
<wicri:noRegion>Department of Medicine, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zeh, Herbert J" sort="Zeh, Herbert J" uniqKey="Zeh H" first="Herbert J." last="Zeh">Herbert J. Zeh</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Surgery, the University of Pittsburgh Medical Center</s1>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Surgery, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zureikat, Amer H" sort="Zureikat, Amer H" uniqKey="Zureikat A" first="Amer H." last="Zureikat">Amer H. Zureikat</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Surgery, the University of Pittsburgh Medical Center</s1>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Surgery, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Kenneth K" sort="Lee, Kenneth K" uniqKey="Lee K" first="Kenneth K." last="Lee">Kenneth K. Lee</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Surgery, the University of Pittsburgh Medical Center</s1>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Surgery, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Allan Tsung" sort="Allan Tsung" uniqKey="Allan Tsung" last="Allan Tsung">ALLAN TSUNG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Surgery, the University of Pittsburgh Medical Center</s1>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Surgery, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mantha, Geeta S" sort="Mantha, Geeta S" uniqKey="Mantha G" first="Geeta S." last="Mantha">Geeta S. Mantha</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, the University of Pittsburgh Medical Center</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Department of Pathology, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khalid, Asif" sort="Khalid, Asif" uniqKey="Khalid A" first="Asif" last="Khalid">Asif Khalid</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, the University of Pittsburgh Medical Center</s1>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<country>États-Unis</country>
<wicri:noRegion>Department of Medicine, the University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>VA Pittsburgh Healthcare System</s1>
<s2>Pittsburgh, Pennsylvania</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Clinical cancer research : (Print)</title>
<title level="j" type="abbreviated">Clin. cancer res. : (Print)</title>
<idno type="ISSN">1078-0432</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Clinical cancer research : (Print)</title>
<title level="j" type="abbreviated">Clin. cancer res. : (Print)</title>
<idno type="ISSN">1078-0432</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (diagnosis)</term>
<term>Adenocarcinoma (genetics)</term>
<term>Adenocarcinoma, Mucinous (diagnosis)</term>
<term>Adenocarcinoma, Mucinous (genetics)</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Biomarkers, Tumor (genetics)</term>
<term>Biopsy, Fine-Needle</term>
<term>C-Onc gene</term>
<term>Carcinoma, Pancreatic Ductal (diagnosis)</term>
<term>Carcinoma, Pancreatic Ductal (genetics)</term>
<term>Carcinoma, Papillary (diagnosis)</term>
<term>Carcinoma, Papillary (genetics)</term>
<term>Chromogranins</term>
<term>Cyst Fluid (chemistry)</term>
<term>Cyst Fluid (metabolism)</term>
<term>Cystadenoma, Serous (diagnosis)</term>
<term>Cystadenoma, Serous (genetics)</term>
<term>Diagnosis</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>GTP-Binding Protein alpha Subunits, Gs (genetics)</term>
<term>Humans</term>
<term>K ras Gene</term>
<term>Male</term>
<term>Medical screening</term>
<term>Middle Aged</term>
<term>Mutation (genetics)</term>
<term>Neoplasm Staging</term>
<term>Pancreatic Cyst (metabolism)</term>
<term>Pancreatic Cyst (pathology)</term>
<term>Pancreatic Neoplasms (diagnosis)</term>
<term>Pancreatic Neoplasms (genetics)</term>
<term>Pancreatic cyst</term>
<term>Preoperative</term>
<term>Preoperative Care</term>
<term>Prognosis</term>
<term>Proto-Oncogene Proteins (genetics)</term>
<term>Proto-Oncogene Proteins p21(ras)</term>
<term>Protooncogene</term>
<term>Young Adult</term>
<term>ras Proteins (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Adénocarcinome (diagnostic)</term>
<term>Adénocarcinome (génétique)</term>
<term>Adénocarcinome mucineux (diagnostic)</term>
<term>Adénocarcinome mucineux (génétique)</term>
<term>Carcinome du canal pancréatique (diagnostic)</term>
<term>Carcinome du canal pancréatique (génétique)</term>
<term>Carcinome papillaire (diagnostic)</term>
<term>Carcinome papillaire (génétique)</term>
<term>Chromogranine</term>
<term>Cystadénome séreux (diagnostic)</term>
<term>Cystadénome séreux (génétique)</term>
<term>Cytoponction</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Kyste du pancréas (anatomopathologie)</term>
<term>Kyste du pancréas (métabolisme)</term>
<term>Liquide kystique ()</term>
<term>Liquide kystique (métabolisme)</term>
<term>Marqueurs biologiques tumoraux (génétique)</term>
<term>Mutation (génétique)</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Protéines G ras (génétique)</term>
<term>Protéines proto-oncogènes (génétique)</term>
<term>Protéines proto-oncogènes p21(ras)</term>
<term>Soins préopératoires</term>
<term>Sous-unités alpha Gs des protéines G (génétique)</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tumeurs du pancréas (diagnostic)</term>
<term>Tumeurs du pancréas (génétique)</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Biomarkers, Tumor</term>
<term>GTP-Binding Protein alpha Subunits, Gs</term>
<term>Proto-Oncogene Proteins</term>
<term>ras Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Kyste du pancréas</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Cyst Fluid</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Adenocarcinoma</term>
<term>Adenocarcinoma, Mucinous</term>
<term>Carcinoma, Pancreatic Ductal</term>
<term>Carcinoma, Papillary</term>
<term>Cystadenoma, Serous</term>
<term>Pancreatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Adénocarcinome</term>
<term>Adénocarcinome mucineux</term>
<term>Carcinome du canal pancréatique</term>
<term>Carcinome papillaire</term>
<term>Cystadénome séreux</term>
<term>Tumeurs du pancréas</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenocarcinoma</term>
<term>Adenocarcinoma, Mucinous</term>
<term>Carcinoma, Pancreatic Ductal</term>
<term>Carcinoma, Papillary</term>
<term>Cystadenoma, Serous</term>
<term>Mutation</term>
<term>Pancreatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénocarcinome</term>
<term>Adénocarcinome mucineux</term>
<term>Carcinome du canal pancréatique</term>
<term>Carcinome papillaire</term>
<term>Cystadénome séreux</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Mutation</term>
<term>Protéines G ras</term>
<term>Protéines proto-oncogènes</term>
<term>Sous-unités alpha Gs des protéines G</term>
<term>Tumeurs du pancréas</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cyst Fluid</term>
<term>Pancreatic Cyst</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Kyste du pancréas</term>
<term>Liquide kystique</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Pancreatic Cyst</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Biopsy, Fine-Needle</term>
<term>Chromogranins</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neoplasm Staging</term>
<term>Preoperative Care</term>
<term>Prognosis</term>
<term>Proto-Oncogene Proteins p21(ras)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Chromogranine</term>
<term>Cytoponction</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Liquide kystique</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Protéines proto-oncogènes p21(ras)</term>
<term>Préopératoire</term>
<term>Gène K ras</term>
<term>Protooncogène</term>
<term>Gène onc cellulaire</term>
<term>Dépistage</term>
<term>Diagnostic</term>
<term>Kyste pancréatique</term>
<term>Soins préopératoires</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études de suivi</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose: Management guidelines for pancreatic intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN) are based on the assumption that mucinous cysts can be accurately distinguished from other pancreatic cystic lesions. Previous studies using surgical material have identified recurrent mutations in GNAS and KRAS in pancreatic mucinous neoplasms. Yet, the diagnostic utility of testing for both genes in pancreatic cyst fluid obtained by endoscopic ultrasound-fine-needle aspiration (EUS-FNA) remains unclear. Experimental Design: GNAS and KRAS testing was performed on EUS-FNA pancreatic cyst fluid from 91 pancreatic cysts: 41 IPMNs, 9 IPMNs with adenocarcinoma, 16 MCNs, 10 cystic pancreatic neuroendocrine tumors (PanNET), 9 serous cystadenomas (SCA), 3 retention cysts, 2 pseudocysts, and 1 lymphoepithelial cyst. Results: Mutations in GNAS were detected in 16 (39%) IPMNs and 2 (22%) IPMNs with adenocarcinoma. KRAS mutations were identified in 28 (68%) IPMNs, 7 (78%) IPMNs with adenocarcinoma, and 1 (6%) MCN. Mutations in either gene were present in 34 (83%) IPMNs, 8 (89%) IPMNs with adenocarcinoma, and 1 (6%) MCN. No mutations were found in cystic PanNETs, SCAs, retention cysts, pseudocysts, and a lymphoepithelial cyst. GNAS and KRAS mutations had 100% specificity [95% confidence interval (CI), 0.83-1.00] but 65% sensitivity (95% CI, 0.52-0.76) for mucinous differentiation. Among IPMNs, mutations in either gene had 98% specificity (95% CI, 0.86-1.00) and 84% sensitivity (95% CI, 0.70-0.92). Conclusions: The combination of GNAS and KRAS testing was highly specific and sensitive for IPMNs; however, the lack of sensitivity for MCNs highlights the need for additional markers to improve the detection of pancreatic mucinous neoplasms.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
</region>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Singhi, Aatur D" sort="Singhi, Aatur D" uniqKey="Singhi A" first="Aatur D." last="Singhi">Aatur D. Singhi</name>
</noRegion>
<name sortKey="Allan Tsung" sort="Allan Tsung" uniqKey="Allan Tsung" last="Allan Tsung">ALLAN TSUNG</name>
<name sortKey="Bartholow, Tanner L" sort="Bartholow, Tanner L" uniqKey="Bartholow T" first="Tanner L." last="Bartholow">Tanner L. Bartholow</name>
<name sortKey="Brand, Randall E" sort="Brand, Randall E" uniqKey="Brand R" first="Randall E." last="Brand">Randall E. Brand</name>
<name sortKey="Chennat, Jennifer S" sort="Chennat, Jennifer S" uniqKey="Chennat J" first="Jennifer S." last="Chennat">Jennifer S. Chennat</name>
<name sortKey="Fasanella, Kenneth E" sort="Fasanella, Kenneth E" uniqKey="Fasanella K" first="Kenneth E." last="Fasanella">Kenneth E. Fasanella</name>
<name sortKey="Khalid, Asif" sort="Khalid, Asif" uniqKey="Khalid A" first="Asif" last="Khalid">Asif Khalid</name>
<name sortKey="Khalid, Asif" sort="Khalid, Asif" uniqKey="Khalid A" first="Asif" last="Khalid">Asif Khalid</name>
<name sortKey="Lee, Kenneth K" sort="Lee, Kenneth K" uniqKey="Lee K" first="Kenneth K." last="Lee">Kenneth K. Lee</name>
<name sortKey="Mantha, Geeta S" sort="Mantha, Geeta S" uniqKey="Mantha G" first="Geeta S." last="Mantha">Geeta S. Mantha</name>
<name sortKey="Mcgrath, Kevin M" sort="Mcgrath, Kevin M" uniqKey="Mcgrath K" first="Kevin M." last="Mcgrath">Kevin M. Mcgrath</name>
<name sortKey="Nikiforova, Marina N" sort="Nikiforova, Marina N" uniqKey="Nikiforova M" first="Marina N." last="Nikiforova">Marina N. Nikiforova</name>
<name sortKey="Ohori, N Paul" sort="Ohori, N Paul" uniqKey="Ohori N" first="N. Paul" last="Ohori">N. Paul Ohori</name>
<name sortKey="Pai, Reetesh K" sort="Pai, Reetesh K" uniqKey="Pai R" first="Reetesh K." last="Pai">Reetesh K. Pai</name>
<name sortKey="Papachristou, Georgios I" sort="Papachristou, Georgios I" uniqKey="Papachristou G" first="Georgios I." last="Papachristou">Georgios I. Papachristou</name>
<name sortKey="Papachristou, Georgios I" sort="Papachristou, Georgios I" uniqKey="Papachristou G" first="Georgios I." last="Papachristou">Georgios I. Papachristou</name>
<name sortKey="Slivka, Adam" sort="Slivka, Adam" uniqKey="Slivka A" first="Adam" last="Slivka">Adam Slivka</name>
<name sortKey="Xuong Lu" sort="Xuong Lu" uniqKey="Xuong Lu" last="Xuong Lu">XUONG LU</name>
<name sortKey="Zeh, Herbert J" sort="Zeh, Herbert J" uniqKey="Zeh H" first="Herbert J." last="Zeh">Herbert J. Zeh</name>
<name sortKey="Zureikat, Amer H" sort="Zureikat, Amer H" uniqKey="Zureikat A" first="Amer H." last="Zureikat">Amer H. Zureikat</name>
</country>
</tree>
</affiliations>
</record>

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Preoperative GNAS and KRAS Testing in the Diagnosis of Pancreatic Mucinous Cysts

Preoperative GNAS and KRAS Testing in the Diagnosis of Pancreatic Mucinous Cysts

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	Serveur d'exploration sur Pittsburgh
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